Going to work every day, with many stuck in traffic, is absolutely not enjoyable for most people most times. Not only that, but the time going to and from work, I'd say, is around an hour on average for most people. That's 1 repetitive, boring, or miserable hour spent usually 5 days a week. Adding to this the usual 9 hours in the office, that's 10 hours a day, 5 days a week for usually years. Seeing the same view and the same walls for so long over and over. Just because it's tolerable and sometimes enjoyable doesn't mean it's not mostly a slightly negative experience.
When I say "coworker interactions are mostly negative", it's a legitimate generality for most office workers in the world, and "negative" doesn't mean horrible; it's just not good. Again, for most people in the world, the nature of their office job is getting paid to do a task, usually not fun and many times hard or boring, working with people they don't know, many times don't like, and having to behave and act a certain contrived way. Solving problems, avoiding others, doing boring work, dealing with coworkers that they don't like or are incompetent or have to impress, or having to prove your competency, having to navigate gossip, competition, etc. I'm not saying it's all terrible and that there aren't great positives. What I'm trying to show is that everything that a job entails is, on average, at least slightly stressful. Those who love their job are the exception and very lucky; everyone knows this.
You said, "The office gives you people who actually notice". Sometimes, but not necessarily. Being stuck in an office with the same people for so many hours naturally creates companionship, but it's not organic; it's circumstance and by necessity. People are there to make money first and foremost. Coworkers were usually strangers before they met in the office for the first time and now have to work together to keep making money. Just because coworkers are friendly and compassionate with each other doesn't mean it's true friendship and understanding. It's normal human decency and working towards improving their workspace they spend 8+ hours in every day. To suggest that coworkers care more when the main reason they're there is for money is difficult to accept.
However, this is not to say there aren't great people and great friendships made in offices, again, i'm speaking in general, on average worldwide.
You also said "Isolation doesn't lower stress". Is a wrong assumption you've made a second time. Again, remote workers aren't mostly working isolated, the oposite is true, they keep working in different places. There're entire bussiness dedicated to receive remote and nomad workers all over the world.
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