Think about split-brain patients. When surgeons sever the corpus callosum, these people sometimes act like two minds are in one skull. One hand unbuttons a shirt while the other buttons it back up. If a soul unified consciousness, that should be impossible. But it happens, because consciousness is an emergent property of physical networks, not a separate substance. When those networks get rewired or cut, the self fragments exactly as you'd predict from a physical system.
The Mary argument is clever, I'll give it that. But it makes a category error. It treats "knowing what red feels like" as if it's a thing floating free from the brain. Yet every case of brain damage, drugs, or sensory deprivation shows that phenomenal knowledge is generated by physical processes. Lose the neurons, lose the feeling. The soul isn't a missing piece of the puzzle; it's a placeholder we invented before we understood the machinery. And as we understand more, the soul explains nothing. That's the real bottom line.