The strongest case against prayer changing anything is that when it is tested in ways that rule out coincidence and placebo, the effect disappears. Controlled studies of intercessory prayer have found no measurable improvement in recovery or outcomes. Prayer may comfort the person praying, and that is real, but comfort is not the same as altering external events. If prayer changed outcomes, we would expect a consistent, detectable pattern. Instead, what we see is consistent with chance, expectation, and natural causes. Personal experiences are understandable, but they are not evidence of a mechanism.